Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells.
نویسندگان
چکیده
We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 10 6 شماره
صفحات -
تاریخ انتشار 2000